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 Formulary Chapter 8: Malignant disease and immunosuppression - Full Chapter
Notes:

NHS England - The Cancer Drugs Fund

 

Please refer to the North East Yorkshire and Humber Clinical Alliance for full cancer guidelines and chemotherapy regimens.

North East Yorkshire and Humber Clinical Alliance

 Details...
08.01  Expand sub section  Cytotoxic drugs
Cemiplimab (Libtayo® )
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Cancer Drugs Fund

Infusion

 
Link  NICE TA592:Cemiplimab for treating metastatic or locally advanced cutaneous squamous cell carcinoma
   
Inotuzumab ozogamicin (Besponsa®)
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Red
High Cost Medicine
Cancer Drugs Fund
NHS England
BlueTeq

infusion

 
Link  NICE TA541:Inotuzumab ozogamicin for treating relapsed or refractory B-cell acute lymphoblastic leukaemia
   
Pegaspargase (Oncaspar®)
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Tablet

 
Link  NICE TA408: Pegaspargase for treating acute lymphoblastic leukaemia
   
08.01  Expand sub section  Side-effects of cytotoxic drugs
08.01  Expand sub section  Drugs for cytotoxic-induced side-effects
Calcium Folinate
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Tablet, injection

 
   
Mesna
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Red

Tablet, injection

 
   
08.01.01  Expand sub section  Alkylating drugs
Bendamustine
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Red
High Cost Medicine
Cancer Drugs Fund
BlueTeq

infusion

 
Link  MHRA Drug safety update: Bendamustine (Levact): increased mortality observed in recent clinical studies in off-label use; monitor for opportunistic infections, hepatitis B reactivation
Link  NICE TA216: Bendamustine for CLL
Link  NICE TA472Obinutuzumab with bendamustine for treating follicular lymphoma refractory to rituximab
   
Cytotoxic Drug Busulfan
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Red

tablet, infusion

 
   
Cytotoxic Drug Carmustine (BiCNU®)
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Red

Injection

 
Link  NICE TA121: Glioma (newly diagnosed and high grade) - carmustine implants and temozolomide
   
Cytotoxic Drug Carmustine (Gliadel®)
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Red

implant

 
Link  NICE TA121: Glioma (newly diagnosed and high grade) - carmustine implants and temozolomide
   
Cytotoxic Drug Chlorambucil
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Red

Tablet

 
   
Cytotoxic Drug Cyclophosphamide
(Chemotherapy)
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Red

Tablet, Injection

 
   
Estramustine Phosphate (Estracyt®)
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Red
 
   
Cytotoxic Drug Ifosfamide (Mitoxana®)
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Red
 
   
Cytotoxic Drug Lomustine
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Red
 
   
Cytotoxic Drug Melphalan
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Red

tablet, Injection

 
   
Thiotepa
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Red

Injection

 
   
Treosulfan
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Red
 
   
08.01.02  Expand sub section  Anthracyclines and other cytotoxic antibiotics to top
Cytotoxic Drug Bleomycin
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Red

injection

 
   
Cytotoxic Drug Dactinomycin (Cosmegen Lyovac®)
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Red

injection

 
   
Daunorubicin (DaunoXome®)
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Red

injection

 
   
Cytotoxic Drug Daunorubicin 44mg and Cytarabine 100mg (Vyxeos®)
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Red

Injection

 
Link  NICE TA552:Liposomal cytarabine–daunorubicin for untreated acute myeloid leukaemia
   
Cytotoxic Drug Doxorubicin
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Red

Injection

 
   
Cytotoxic Drug Doxorubicin (Caelyx®)
(Liposomal)
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Red
High Cost Medicine
Cancer Drugs Fund
BlueTeq

Concentrate for intravenous infusion

 
Link  NICE TA389 - Topotecan, pegylated liposomal doxorubicin hydrochloride, paclitaxel, trabectedin and gemcitabine for treating recurrent ovarian cancer
Link  NICE TA440 : Pegylated liposomal irinotecan for treating pancreatic cancer after gemcitabine
   
Cytotoxic Drug Epirubicin
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Red

Injection

 
   
Cytotoxic Drug Idarubicin (Zavedos®)
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Red

Capsule, injection

 
   
Cytotoxic Drug Mitomycin
(injection, bladder)
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Red

Injection, bladder instillation

 
   
Mitoxantrone (Onkotrone®)
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Red

Infusion

 
   
Cytotoxic Drug Mitoxantrone (Mitozantrone)
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Red

Infusion

 
   
Cytotoxic Drug Pixantrone
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Red
High Cost Medicine
 
Link  NICE TA306: Pixantrone monotherapy
   
08.01.03  Expand sub section  Antimetabolites
Cytotoxic Drug Azacitidine (Vidaza®)
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Red
High Cost Medicine

Injection

 
Link  NICE TA218: azacitidine for myelodysplastic syndromes
Link  NICE TA399: Azacitidine for treating acute myeloid leukaemia with more than 30% bone marrow blasts
   
Cytotoxic Drug Capecitabine (Xeloda®)
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Red

Tablet

 
Link  MHRA Drug Safety Update: Capecitabine: risk of severe skin reactions - discontinue treatment
Link  NICE TA100: Colon cancer (adjuvant) - capecitabine and oxaliplatin
Link  NICE TA191: Gastric cancer (advanced) - capecitabine
Link  NICE TA60: Colorectal cancer - capecitabine and tegafur uracil
   
Cytotoxic Drug Cladribine
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Formulary
Red
High Cost Medicine

Infusion

 
Link  MHRA Drug safety alert:Cladribine (Litak, Leustat) for leukaemia: reports of progressive multifocal encephalopathy (PML); stop treatment if PML suspected
   
Cladribine (Mavenclad®)
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Red
High Cost Medicine
NHS England

Tablet

 
Link  NICE TA493:Cladribine tablets for treating relapsing–remitting multiple sclerosis
   
Cytotoxic Drug Clofarabine (Evoltra®)
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Red
High Cost Medicine
Cancer Drugs Fund
BlueTeq

Intravenous infusion

 
   
Cytotoxic Drug Cytarabine (DepoCyte®)
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Red

lipid formulation for intrathecal use

 
   
Cytotoxic Drug Fludarabine Phosphate (Fludara®)
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Red

Tablet, Injection

 
Link  NICE TA119: Leukaemia (lymphocytic) - fludarabine
Link  NICE TA29: Leukaemia (lymphocytic) - fludarabine
   
Cytotoxic Drug Fluorouracil
(Chemotherapy)
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Red
 
   
Fluorouracil
(Efudix)
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Amber

cream

For dermatology indications

 
   
Cytotoxic Drug Gemcitabine (Gemzar®)
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Red

injection

 
Link  NICE TA116: Breast cancer - gemcitabine
Link  NICE TA25: Pancreatic cancer - gemcitabine
Link  NICE TA389 - Topotecan, pegylated liposomal doxorubicin hydrochloride, paclitaxel, trabectedin and gemcitabine for treating recurrent ovarian cancer
   
Cytotoxic Drug Mercaptopurine
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Red

tablet, suspension

 
   
Cytotoxic Drug Methotrexate
(Chemotherapy)
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Red

Injection

 
   
Nelarabine (Atriance®)
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Red
High Cost Medicine
Cancer Drugs Fund
BlueTeq

Intravenous Infusion

 
   
Cytotoxic Drug Pemetrexed (Alimta®)
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Red
High Cost Medicine
Cancer Drugs Fund

Injection

 
Link  NICE TA135: Mesothelioma - pemetrexed disodium
Link  NICE TA181: Lung cancer (non-small cell, first line treatment) - pemetrexed
Link  NICE TA190: Lung cancer (non-small-cell) - pemetrexed (maintenance)
Link  NICE TA402: Pemetrexed maintenance treatment for non-squamous non-small-cell lung cancer after pemetrexed and cisplatin
   
Cytotoxic Drug Raltitrexed (Tomudex®)
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Red
High Cost Medicine

Infusion

 
   
Cytotoxic Drug Tegafur with Uracil (Uftoral®)
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Formulary
Red

Capsule

 
Link  NICE TA61: Capcitabine and tegafur - Colorectal cancer
   
Cytotoxic Drug Tioguanine (Lanvis®)
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Red

Tablet

 
   
08.01.04  Expand sub section  Vinca alkaloids and etoposide
Etoposide (Etopophos®)
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Red

Capsule, Infusion

 
   
Cytotoxic Drug Vinblastine Sulphate
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Formulary
Red

Injection

 
   
Cytotoxic Drug Vincristine Sulphate
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Formulary
Red

injection

 
   
Cytotoxic Drug Vindesine Sulphate (Eldisine®)
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Red

injection

 
   
Cytotoxic Drug Vinorelbine
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Red

Injection, capsule

 
   
08.01.05  Expand sub section  Other antineoplastic drugs
Alectinib (Alecensa®)
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Formulary
Red
High Cost Medicine
BlueTeq

CAPSULE

 
Link  NICE TA536:Alectinib for untreated ALK-positive advanced non-small-cell lung cancer
   
Axitinib (Inlyta®)
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Red
High Cost Medicine

Tablet

 
Link  NICE TA333: Axitinib for advanced renal cell carcinoma
   
Bosutinib (Bosulif®)
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Red
High Cost Medicine
Cancer Drugs Fund
NHS England
BlueTeq

Tablet

 
Link  NICE TA401: Bosutinib for previously treated chronic myeloid leukaemia
   
Carfilzomib (Kyprolis®)
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Formulary
Red
High Cost Medicine
NHS England
BlueTeq

Powder for infusion

 
Link  MHRA Drug Safety Alert:Carfilzomib (Kyprolis¥): reminder of risk of potentially fatal cardiac events
Link  NICE TA457:Carfilzomib for previously treated multiple myeloma
   
Ceritinib (Zykadia)
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Formulary
Red
High Cost Medicine
NHS England
BlueTeq

Capsule

 
Link  NICE TA395: Ceritinib for previously treated anaplastic lymphoma kinase positive non-small-cell lung cancer
Link  NICE TA500:Ceritinib for untreated ALK-positive non-small-cell lung cancer
   
Dabrafenib (Tafinlar®)
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Formulary
Red
High Cost Medicine
Cancer Drugs Fund

capsule

 
Link  NICE TA321:Dabrafenib for BRAF V600 +ve melanoma
Link  NICE TA396:Trametinib in combination with dabrafenib for treating unresectable or metastatic melanoma
   
Cytotoxic Drug Eribulin (Halaven®)
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Formulary
Red
High Cost Medicine
Cancer Drugs Fund
NHS England
BlueTeq

Injection

 
Link  NICE TA423: Eribulin for treating locally advanced or metastatic breast cancer after 2 or more chemotherapy regimens
Link  NICE TA515:Eribulin for treating locally advanced or metastatic breast cancer after 1 chemotherapy regimen
   
Ibrutinib (Imbruvica®)
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Formulary
Red
High Cost Medicine
Cancer Drugs Fund

Capsule, Tablet

 
Link  MHRA Drug Safety Update: Ibrutinib (Imbruvica): reports of ventricular tachyarrhythmia; risk of hepatitis B reactivation and of opportunistic infections - August 2017
Link  NICE TA429 : Ibrutinib for previously treated chronic lymphocytic leukaemia and untreated chronic lymphocytic leukaemia with 17p deletion or TP53 mutation
   
Idelalisib (Zydelig®)
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Red
 
Link  NICE TA359: Chronic lymphocytic leukaemia - Idelalisib
   
Ixazomib (Ninlaro®)
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Formulary
Red
High Cost Medicine
Cancer Drugs Fund

Capsule

 
Link  NICE TA505:Ixazomib with lenalidomide and dexamethasone for treating relapsed or refractory multiple myeloma
   
Lenvatinib (Lenvima® and Kisplyx®)
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Red
High Cost Medicine
NHS England
BlueTeq

Capsule

To be prescribed by brand

 
Link  NICE TA535:Lenvatinib and sorafenib for treating differentiated thyroid cancer after radioactive iodine
Link  NICE TA55:Lenvatinib for untreated advanced hepatocellular carcinoma
   
Midostaurin (Rydapt® )
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Red
High Cost Medicine
BlueTeq

Capsule

 
Link  NICE TA523:Midostaurin for untreated acute myeloid leukaemia
   
Nintedanib (Vargatef ®)
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Red
High Cost Medicine

Tablet

 
Link  NICE TA347:Nintedanib for previously treated locally advanced, metastatic, or locally recurrent non‑small‑cell lung cancer
   
Olaratumab (Lartruvo® )
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Formulary
Red
High Cost Medicine

Injection

 
   
Cytotoxic Drug Panitumumab (Vectibix®)
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Formulary
Red
High Cost Medicine
Cancer Drugs Fund
 
Link  NICE TA439 : Cetuximab and panitumumab for previously untreated metastatic colorectal cancer
   
Cytotoxic Drug Panobinostat (Farydak®)
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Formulary
Red
High Cost Medicine

tablet

 
Link  NICE TA380: Panobinostat for treating multiple myeloma after at least 2 previous treatments
   
Pembrolizumab (Keytruda®)
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Formulary
Red
High Cost Medicine
Cancer Drugs Fund
BlueTeq

infusion

 
Link  NICE TA357: Pembrolizumab for melanoma after ipilimumab
Link  NICE TA366: Pembrolizumab for advanced melanoma not previously treated with ipilimumab
Link  NICE TA428: Pembrolizumab for treating PD-L1-positive non-small-cell lung cancer after chemotherapy
   
Ponatinib (Iclusig®)
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Red
High Cost Medicine
Cancer Drugs Fund
 
   
Ruxolitinib (Jakavi®)
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Formulary
Red
High Cost Medicine

Tablet

 
Link  NICE TA386: Ruxolitinib for treating disease-related splenomegaly or symptoms in adults with myelofibrosis
   
Cytotoxic Drug Talimogene laherparepvec (Imlygic®)
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Red
High Cost Medicine
 
Link  NICE TA410: Talimogene laherparepvec for treating unresectable metastatic melanoma
   
Trametinib (Mekinist®)
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Formulary
Red
High Cost Medicine
Cancer Drugs Fund
NHS England
BlueTeq

Tablet

 
Link  MHRA Drug Safety Alert:Trametinib (Mekinist¥): risk of gastrointestinal perforation and colitis
Link  NICE TA396: Trametinib in combination with dabrafenib for treating unresectable or metastatic melanoma
Link  NICE TA544:Dabrafenib with trametinib for adjuvant treatment of resected BRAF V600 mutation-positive melanoma
   
Trifluridine and Tipiracil  (Lonsurf ®)
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Formulary
Red
High Cost Medicine
Cancer Drugs Fund
BlueTeq

Tablet

 
Link  NICE TA405:Trifluridine–tipiracil for previously treated metastatic colorectal cancer
   
Venetoclax (Venclyxto ® )
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Formulary
Red
High Cost Medicine
Cancer Drugs Fund
BlueTeq

Tablet

 
Link  NICE TA561:Venetoclax with rituximab for previously treated chronic lymphocytic leukaemia
   
Vosaroxin (Qinprezo)
View adult BNF View SPC online View childrens BNF  Track Changes
Restricted Drug Restricted
Red
High Cost Medicine

Injection

 
   
08.01.05  Expand sub section  Amsacrine
08.01.05  Expand sub section  Arsenic trioxide to top
Cytotoxic Drug Arsenic Trioxide (Trisenox®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
BlueTeq

Infusion

 
Link  NICE TA526:Arsenic trioxide for treating acute promyelocytic leukaemia
   
08.01.05  Expand sub section  Bevacizumab
Bevacizumab (Avastin®)
(Oncology)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
Cancer Drugs Fund
BlueTeq

Infusion

 
Link  MHRA Safety Alert:Bevacizumab and sunitinib: risk of osteonecrosis of the jaw
Link  NICE TA214: Breast Cancer with taxane
Link  NICE TA263: Breast cancer with capecitabine
Link  NICE TA284:Bevacizumab in combination with paclitaxel and carboplatin for first-line treatment of advanced ovarian cancer
Link  NICE TA285: Ovarian, fallopian tube and primary peritoneal cancer (recurrent advanced, platinum-sensitive or partially platinum-sensitive) - bevacizumab
   
08.01.05  Expand sub section  Bexarotene
Bexarotene (Targretin®)
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Formulary
Red
High Cost Medicine
NHS England
 
   
08.01.05  Expand sub section  Bortezomib
Cytotoxic Drug Bortezomib (Velcade®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
Cancer Drugs Fund
BlueTeq
 
Link  NICE TA129: Multiple myeloma - bortezomib
Link  NICE TA228: 1st line treatment of multiple myeloma
Link  NICE TA311: Bortezomib for induction therapy in multiple myeloma
Link  NICE TA370: Bortezomib for previously untreated mantle cell lymphoma
   
08.01.05  Expand sub section  Brentuximab vedotin
Brentuximab vedotin (Adcetris®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
Cancer Drugs Fund

infusion

 
Link  NICE TA478: Brentuximab vedotin for treating relapsed or refractory systemic anaplastic large cell lymphoma
Link  NICE TA524:Brentuximab vedotin for treating CD30-positive Hodgkin lymphoma
Link  NICE TA577:Brentuximab vedotin for treating CD30-positive cutaneous T-cell lymphoma
Link  NICE TA594: Brentuximab vedotin for untreated advanced Hodgkin lymphoma (terminated appraisal)
   
08.01.05  Expand sub section  Cetuximab to top
Cetuximab (Erbitux®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
Cancer Drugs Fund
NHS England
BlueTeq

Injection

 
Link  MHRA Drug Safety Alert:Cetuximab: new safety information available
Link  NICE TA145: Head and neck cancer - cetuximab
Link  NICE TA176: Colorectal cancer (first line) - cetuximab
Link  NICE TA242:Cetuximab, bevacizumab and panitumumab for the treatment of metastatic colorectal cancer after first-line chemotherapy: Cetuximab (monotherapy or combination chemotherapy), bevacizumab (in combination with non-oxaliplatin chemotherapy) and pani
Link  NICE TA439 : Cetuximab and panitumumab for previously untreated metastatic colorectal cancer
Link  NICE TA473:Cetuximab for treating recurrent or metastatic squamous cell cancer of the head and neck
   
08.01.05  Expand sub section  Crisantaspase
Crisantaspase (Erwinase®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
 
   
08.01.05  Expand sub section  Dacarbazine and Temozolomide
Cytotoxic Drug Dacarbazine
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red

Injection

 
   
Cytotoxic Drug Temozolomide (Temodal®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine

capsule

 
Link  MHRA Drug Safety Alert: Temozolomide: risk of hepatic injury, including fatal hepatic failure—updated warnings and monitoring guidance
Link  MHRA Drug Safety Alert: Temozolomide: risk of hepatic injury, including fatal hepatic failure—updated warnings and monitoring guidance
Link  NICE TA121: Glioma (newly diagnosed and high grade)
Link  NICE TA23: Guidance on the use of temozolomide for the treatment of recurrent malignant glioma (brain cancer)
   
08.01.05  Expand sub section  Erlotinib
Erlotinib (Tarceva® )
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine

Tablets

 
Link  NICE TA227: Lung cancer (non-small-cell) maintenance - erlotinib
Link  NICE TA258: Lung cancer (non-small-cell) 1st line- erlotinib
Link  NICE TA374: Erlotinib and gefitinib for treating non-small-cell lung cancer that has progressed after prior chemotherapy
   
08.01.05  Expand sub section  Hydroxycarbamide
Cytotoxic Drug Hydroxycarbamide
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber

Capsule

 
   
08.01.05  Expand sub section  Imatinab to top
08.01.05  Expand sub section  Ipilimumab
Ipilimumab (Yervoy®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
Cancer Drugs Fund
NHS England
BlueTeq

Concentrate for intravenous infusion

 
Link  MHRA Drug Safety Alert:Ipilimumab (Yervoy): reports of cytomegalovirus (CMV) gastrointestinal infection or reactivation
Link  NICE TA268: Ipilimumab for previously treated advanced (unresectable or metastatic) melanoma
Link  NICE TA319: Ipilimumab for previously untreated advanced (unresectable or metastatic) melanoma
Link  NICE TA400: Nivolumab in combination with ipilimumab for treating advanced melanoma
Link  NICE TA581:Nivolumab with ipilimumab for untreated advanced renal cell carcinoma
   
08.01.05  Expand sub section  Mitotane
08.01.05  Expand sub section  Panitumumab
08.01.05  Expand sub section  Pentostatin
Cytotoxic Drug Pentostatin (Nipent®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red

Injection

 
   
08.01.05  Expand sub section  Platinum compounds to top
Cytotoxic Drug Carboplatin
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red

Injection

 
   
Cytotoxic Drug Cisplatin
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Formulary
Red

Injection

 
   
Cytotoxic Drug Oxaliplatin
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red

Injection

 
Link  NICE TA100: Colon cancer (adjuvant) - capecitabine and oxaliplatin
   
Oxaliplatin (Eloxatin®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
 
   
08.01.05  Expand sub section  Porfimer sodium and temoporfin
08.01.05  Expand sub section  Procarbazine
Cytotoxic Drug Procarbazine
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red

capsule 

 
   
08.01.05  Expand sub section  Protein kinase inhibitors
Afatinib (Giotrif®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
 
Link  NICE TA310: Afatinib for treating epidermal growth factor receptor mutation-positive locally advanced or metastatic non-small-cell lung cancer
   
Cabozantinib (Cabometyx®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
Cancer Drugs Fund

Tablet

 
Link  NICE TA463: Cabozantinib for previously treated advanced renal cell carcinoma
Link  NICE TA542: Cabozantinib for untreated advanced renal cell carcinoma
   
Crizotinib (Xalkori®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
Cancer Drugs Fund
NHS England
BlueTeq

Capsule

 
Link  NICE TA406: Crizotinib for untreated anaplastic lymphoma kinase-positive advanced non-small-cell lung cancer
Link  NICE TA422: Crizotinib for previously treated anaplastic lymphoma kinase-positive advanced non-small-cell lung cance
   
Dasatinib (Sprycel®)
View adult BNF View SPC online View childrens BNF  Track Changes
Restricted Drug Restricted
Red
High Cost Medicine
Cancer Drugs Fund
NHS England
BlueTeq

Tablet

Powder for oral Suspension

 
Link  NICE TA241: CML where treatment with imatinib has failed
Link  NICE TA425: Dasatinib, nilotinib and high-dose imatinib for treating imatinib-resistant or intolerant chronic myeloid leukaemia
Link  NICE TA426: Dasatinib, nilotinib and imatinib for untreated chronic myeloid leukaemia
   
Erlotinib (Tarceva®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine

Tablets

 
Link  NICE TA227: Lung cancer (non-small-cell) maintenance - erlotinib
Link  NICE TA258 Lung cancer (non small cell, EGFR-TK mutation positive) - erlotinib (1st line)
Link  NICE TA374: Erlotinib and gefitinib for treating non-small-cell lung cancer that has progressed after prior chemotherapy
   
Everolimus (Afinitor®)
View adult BNF View SPC online View childrens BNF  Track Changes
Restricted Drug Restricted
Red
High Cost Medicine
Cancer Drugs Fund
BlueTeq

Tablets

 
Link  NICE TA348: Preventing Rejection in Liver Transplant
Link  NICE TA421: Everolimus with exemestane for treating advanced breast cancer after endocrine therapy
   
Everolimus (Votubia®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine

Tablet

Dispersible tablet

 
   
Gefitinib (Iressa®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine

Tablet

 
Link  NICE TA192: Lung cancer (non-small-cell, first line) - gefitinib
Link  NICE TA374: Erlotinib and gefitinib for treating non-small-cell lung cancer that has progressed after prior chemotherapy
   
Cytotoxic Drug Imatinib (Gilvec®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine

tablet

 
Link  NICE TA209: Imatinib for the treatment of unresectable and/or metastatic gastrointestinal stromal tumours
Link  NICE TA326:Imatinib for the adjuvant treatment of gastrointestinal stromal tumours
Link  NICE TA426:Dasatinib, nilotinib and imatinib for untreated chronic myeloid leukaemia
Link  NICE TA70:Guidance on the use of imatinib for chronic myeloid leukaemia
Link  NICE TA86: Imatinib for the treatment of unresectable and/or metastatic gastro-intestinal stromal tumours
   
Nilotinib (Tasigna®)
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Formulary
Red
High Cost Medicine
 
Link  NICE TA241: Dasatinib, nilotinib and high dose imatinib for CML
Link  NICE TA251: Dasatinib, nilotinib and imatinib for first line treatment of CML
Link  NICE TA425: Dasatinib, nilotinib and high-dose imatinib for treating imatinib-resistant or intolerant chronic myeloid leukaemia
Link  NICE TA426: Dasatinib, nilotinib and imatinib for untreated chronic myeloid leukaemia
   
Pazopanib (Votrient®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine

Tablet

 
Link  NICE TA215: Pazopanib in renal cell cancer
   
Regorafenib (Stivarga® )
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
Cancer Drugs Fund
BlueTeq

Injection

 
Link  NICE TA334:Regorafenib for metastatic colorectal cancer after treatment for metastatic disease (terminated appraisal)
Link  NICE TA448:Regorafenib for previously treated unresectable or metastatic gastrointestinal stromal tumours
Link  NICE TA555:Regorafenib for previously treated advanced hepatocellular carcinoma
   
Cytotoxic Drug Sorafenib (Nexavar®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
Cancer Drugs Fund
NHS England
BlueTeq

Tablet

 
Link  NICE TA178: Renal cell carcinoma
Link  NICE TA474: Sorafenib for treating advanced hepatocellular carcinoma
Link  NICE TA535: Lenvatinib and sorafenib for treating differentiated thyroid cancer after radioactive iodine
   
Sunitinib (Sutent®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
Cancer Drugs Fund
NHS England
BlueTeq

Capsule

 
Link  MHRA Drug Safety Alert:Bevacizumab and sunitinib: risk of osteonecrosis of the jaw
Link  NICE TA169: Renal cell carcinoma - sunitinib
Link  NICE TA178:Bevacizumab (first-line), sorafenib (first- and second-line), sunitinib (second-line) and temsirolimus (first-line) for the treatment of advanced and/or metastatic renal cell carcinoma
Link  NICE TA179: Gastrointestinal stromal tumours - sunitinib
Link  NICE TA449:Everolimus and sunitinib for treating unresectable or metastatic neuroendocrine tumours in people with progressive disease
   
Cytotoxic Drug Temsirolimus (Torisel®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
Cancer Drugs Fund

infusion

 
Link  NICE TA178: Renal cell carcinoma
   
Tivozanib ((Fotivda®) )
((Fotivda®) )
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
NHS England
BlueTeq

Capsule 

 
Link  NICE TA512:Tivozanib for treating advanced renal cell carcinoma
   
Vemurafenib  ((Zelboraf® ))
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine

tablet

 
   
Vemurafenib (Zelboraf®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine

Tablets

 
Link  MHRA Drug Safety Alert:Vemurafenib (Zelboraf▼): risk of potentiation of radiation toxicity
Link  NICE TA269: Vemurafenib for treating malignant melanoma
   
08.01.05  Expand sub section  Taxanes
Cytotoxic Drug Cabazitaxel (Jevtana®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
NHS England
BlueTeq

infusion

 
Link  MHRA Drug Safety Alert:Cabazitaxel (Jevtana▼): risk of medication error resulting in overdose
Link  NICE TA391: Cabazitaxel for hormone-relapsed metastatic prostate cancer treated with docetaxel
   
Cytotoxic Drug Docetaxel (Taxotere®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine

Injection

 
Link  NICE TA101: Prostate cancer (hormone-refractory) - docetaxel
Link  NICE TA109: Breast cancer (early) - docetaxel
   
Cytotoxic Drug Paclitaxel
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red

Injection

 
Link  NICE TA108: Breast cancer (early) - paclitaxel
Link  NICE TA389 - Topotecan, pegylated liposomal doxorubicin hydrochloride, paclitaxel, trabectedin and gemcitabine for treating recurrent ovarian cancer
Link  NICE TA55:Guidance on the use of paclitaxel in the treatment of ovarian cancer
   
Cytotoxic Drug Paclitaxel - Albumin Bound Formulation (Abraxane®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
NHS England
BlueTeq

Intravenous Infusion

 
Link  NICE TA360: Pancreatic cancer - paclitaxel with gemcitabine
   
08.01.05  Expand sub section  Topoisomerase I inhibitors to top
Cytotoxic Drug Irinotecan Hydrochloride
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red

Infusion

 
   
Cytotoxic Drug Topotecan (Hycamtin®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red

Capsule and Injection

 
Link  NICE TA183: Cervical cancer (recurrent) - topotecan
Link  NICE TA184: Lung cancer (small-cell) - topotecan
Link  NICE TA389 - Topotecan, pegylated liposomal doxorubicin hydrochloride, paclitaxel, trabectedin and gemcitabine for treating recurrent ovarian cancer
   
08.01.05  Expand sub section  Trabectedin
Cytotoxic Drug Trabectedin (Yondelis®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red

Injection

 
Link  NICE TA185: Soft tissue sarcoma - trabectedin
Link  NICE TA389 - Topotecan, pegylated liposomal doxorubicin hydrochloride, paclitaxel, trabectedin and gemcitabine for treating recurrent ovarian cancer
   
08.01.05  Expand sub section  Trastuzumab
Cytotoxic Drug Pertuzumab (Perjeta®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
Cancer Drugs Fund
NHS England
BlueTeq

Infusion

 
Link  NICE TA424: Pertuzumab for the neoadjuvant treatment of HER2-positive breast cancer
Link  NICE TA509:Pertuzumab with trastuzumab and docetaxel for treating HER2-positive breast cancer
Link  NICE TA569:Pertuzumab for adjuvant treatment of HER2-positive early stage breast cancer
   
Cytotoxic Drug Trastuzumab (Herceptin®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
NHS England
BlueTeq

Injection

 
Link  NICE TA208: Gastric cancer (HER2-positive metastatic) - trastuzumab
Link  NICE TA257: in combination with an aromatase inhibitor for HER2 positive metastatic breast cancer
Link  NICE TA34: Breast cancer - trastuzumab
   
Cytotoxic Drug Trastuzumab emtansine (Kadcyla®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
Cancer Drugs Fund
NHS England
BlueTeq

Infusion

 
Link  NICE TA458:Trastuzumab emtansine for treating HER2-positive advanced breast cancer after trastuzumab and a taxane
   
08.01.05  Expand sub section  Tretinoin
Tretinoin (Vesanoid®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red

Capsule 

 
   
08.01.05  Expand sub section  Vismodegib
08.02  Expand sub section  Drugs affecting the immune response to top
Blinatumomab (Blincyto®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
Cancer Drugs Fund
NHS England
BlueTeq

Infusion

 
Link  NICE TA450:Blinatumomab for previously treated Philadelphia-chromosome-negative acute lymphoblastic leukaemia
Link  NICE TA589:Blinatumomab for treating acute lymphoblastic leukaemia in remission with minimal residual disease activity
   
08.02  Expand sub section  Immunosuppressant therapy
08.02.01  Expand sub section  Antiproliferative immunosuppressants
Azathioprine
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber

Tablets 25mg, 50mg

 
   
Mycophenolate Mofetil
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
 
   
Mycophenolate Sodium (Myfortic®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
 
   
08.02.02  Expand sub section  Corticosteroids and other immunosuppressants
AdoPORT ® (Tacrolimus)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber

Red NHSE funded indication are usually Hospital Only

 
   
Advagraf ®
(Tacrolimus)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber

Red NHSE funded indication are usually Hospital Only

 
   
Basiliximab (Simulect®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine

Injection 

 
Link  MHRA Drug Safety Alert: Basiliximab: indicated for renal transplantation only; efficacy and safety not shown in heart transplantation
Link  NICE TA85: Immunosuppressives in renal transplant (Adults)
Link  NICE TA99: Immunosuppressives in renal transplant (Children)
   
Ciclosporin
(transplants)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber
High Cost Medicine

Capsules,

Oral, Solution

Red Injection

Red NHSE funded indication are usually Hospital Only

 

 
   
Daclizumab (Zenapax®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
 
Link  NICE TA441 : Daclizumab for treating relapsing–remitting multiple sclerosis
   
Prograf ®
(Tacrolimus)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber

Red NHSE funded indication are usually Hospital Only

 
   
Cytotoxic Drug Sirolimus (Rapamune®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
 
   
08.02.03  Expand sub section  Anti-lymphocyte monoclonal antibodies
Alemtuzumab (Lemtrada®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
NHS England
BlueTeq

infusion

 
Link  MHRA Drug Safety Alert :Lemtrada (alemtuzumab) and serious cardiovascular and immune-mediated adverse reactions: new restrictions to use and strengthened monitoring requirements
Link  NICE TA312: Alemtuzumab for relapsing‑remitting multiple sclerosis
   
Gemtuzumab ozogamicin
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red

injection

 
   
Obinutuzumab (Gazyvaro ®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
NHS England
BlueTeq

infusion

 
Link  NICE TA 513:Obinutuzumab for untreated advanced follicular lymphoma
Link  NICE TA343: Obinutuzumab with chlorambucil for CLL
Link  NICE TA472:Obinutuzumab with bendamustine for treating follicular lymphoma refractory to rituximab
   
Ocrelizumab (Ocrevus®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
NHS England

Infusion

 
Link   NICE TA533:Ocrelizumab for treating relapsing–remitting multiple sclerosis
Link  NICE TA585:Ocrelizumab for treating primary progressive multiple sclerosis
   
Ofatumumab (Arzerra®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine

Infusion

 
Link  MHRA Drug Safety Alert:Ofatumumab: screen for hepatitis B virus before treatment
Link  MHRA Drug Safety Alert:Ofatumumab¥: reminder of risk of serious and fatal infusion reactions
Link  NICE TA202:Ofatumumab for the treatment of chronic lymphocytic leukaemia refractory to fludarabine and alemtuzumab
Link  NICE TA344: Ofatumumab with chlorambucil or bendamustine for CLL
Link  NICE TA472:Obinutuzumab with bendamustine for treating follicular lymphoma refractory to rituximab
   
Rituximab (MabThera®Truxima ®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
BlueTeq

Injection

 
Link  NICE ESUOM35: Immune (idiopathic) thrombocytopenic purpura: rituximab – evidence summary
Link  NICE TA174:Rituximab for the first-line treatment of chronic lymphocytic leukaemia
Link  NICE TA193:Rituximab for the treatment of relapsed or refractory chronic lymphocytic leukaemia
Link  NICE TA226:Rituximab for the first-line maintenance treatment of follicular non-Hodgkin’s lymphoma
Link  NICE TA243:Rituximab for the first-line treatment of stage III-IV follicular lymphoma
   
08.02.04  Expand sub section  Other immunomodulating drugs to top
Atezolizumab  ((Tecentriq®))
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
Cancer Drugs Fund
BlueTeq

Concentrate for solution for infusion 

 
Link  NICE TA492:Atezolizumab for untreated PD-L1-positive locally advanced or metastatic urothelial cancer when cisplatin is unsuitable
Link  NICE TA520:Atezolizumab for treating locally advanced or metastatic non-small-cell lung cancer after chemotherapy
Link  NICE TA525: Atezolizumab for treating locally advanced or metastatic urothelial carcinoma after platinum-containing chemotherapy
Link  NICE TA584:Atezolizumab in combination for treating metastatic non-squamous non-small-cell lung cancer
   
Controlled Drug Avelumab  ((Bavencio®))
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
Cancer Drugs Fund
BlueTeq

Concentrate for solution for infusion

 
Link  NICE TA 517:Avelumab for treating metastatic Merkel cell carcinoma
   
Axicabtagene ciloleuce ((Yescarta®))
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
Cancer Drugs Fund
BlueTeq
 
Link  NICE TA 559:Axicabtagene ciloleucel for treating diffuse large B-cell lymphoma and primary mediastinal large B-cell lymphoma after 2 or more systemic therapies
   
Daratumumab ( (Darzalex®))
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
Cancer Drugs Fund
BlueTeq

Solution for infusion

 
Link  MHRA Drug safety update:Daratumumab (Darzalex¥): risk of reactivation of hepatitis B virus
Link  NICE TA 510:Daratumumab monotherapy for treating relapsed and refractory multiple myeloma
Link  NICE TA573:Daratumumab with bortezomib and dexamethasone for previously treated multiple myeloma
   
Dimethyl fumarate (Tecfidera®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
NHS England
CCG
 
Link  NICE TA320: Dimethyl fumarate for multiple sclerosis
   
Dinutuximab  ((Qarziba®))
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
Cancer Drugs Fund
BlueTeq
 
Link  NICE TA538:Dinutuximab beta for treating neuroblastoma
   
Durvalumab  ( (Imfinzi® ))
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
Cancer Drugs Fund
BlueTeq

concentrate for solution for infusion

 
Link  NICE TA578:Durvalumab for treating locally advanced unresectable non-small-cell lung cancer after platinum-based chemoradiation
   
Fingolimod
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
 
Link  NICE TA254: Fingolimod for highly active relapsing remitting multiple sclerosis
   
Immunocellular therapy containing tisagenlecleucel, autologous T cells genetically modified ex vivo using a lentiviral vector encoding an anti-CD19 chimeric antigen receptor (CAR) ((Kymriah®))
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
Cancer Drugs Fund
BlueTeq
 
Link  NICE TA554:Tisagenlecleucel for treating relapsed or refractory B-cell acute lymphoblastic leukaemia in people aged up to 25 years
Link  NICE TA567:Tisagenlecleucel for treating relapsed or refractory diffuse large B-cell lymphoma after 2 or more systemic therapies
   
Lenalidomide
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
Cancer Drugs Fund
BlueTeq

Capsule

 
Link  MHRA Safety Update: Lenalidomide (Revlimid¥): update on risk of second primary malignancy
Link  MHRA Safety Update: Lenalidomide: risk of thrombosis and thromboembolism
Link  MHRA Safety Update:Lenalidomide (Revlimid): risk of serious hepatic adverse drug reactions
Link  NICE TA322:Lenalidomide for treating myelodysplastic syndromes associated with an isolated deletion 5q cytogenetic abnormality
Link  NICE TA505:Ixazomib with lenalidomide and dexamethasone for treating relapsed or refractory multiple myeloma
Link  NICE TA586:Lenalidomide plus dexamethasone for multiple myeloma after 1 treatment with bortezomib
Link  NICE TA587:Lenalidomide plus dexamethasone for previously untreated multiple myeloma
   
Niraparib ((Zejula®))
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
Cancer Drugs Fund
BlueTeq

Capsule

 
Link  NICE TA528:Niraparib for maintenance treatment of relapsed, platinum-sensitive ovarian, fallopian tube and peritoneal cancer
   
Nivolumab (Opdivo®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
Cancer Drugs Fund
BlueTeq
 
Link  NICE TA384: Nivolumab for treating advanced (unresectable or metastatic) melanoma
Link  NICE TA400: Nivolumab in combination with ipilimumab for treating advanced melanoma
Link  NICE TA417: Nivolumab for previously treated advanced renal cell carcinoma
Link  NICE TA462: Nivolumab for treating relapsed or refractory classical Hodgkin lymphoma
Link  NICE TA483: Nivolumab for previously treated squamous non-small-cell lung cancer
Link  NICE TA484: Nivolumab for previously treated non-squamous non-small-cell lung cancer
Link  NICE TA490:Nivolumab for treating squamous cell carcinoma of the head and neck after platinum-based chemotherapy
Link  NICE TA530: Nivolumab for treating locally advanced unresectable or metastatic urothelial cancer after platinum-containing chemotherapy
Link  NICE TA558:Nivolumab for adjuvant treatment of completely resected melanoma with lymph node involvement or metastatic disease
Link  NICE TA581:Nivolumab with ipilimumab for untreated advanced renal cell carcinoma
   
Olaparib (Lynparza®)
View adult BNF View SPC online  Track Changes
Formulary
Red
High Cost Medicine
 
Link  NICE TA381: Olaparib guidance
   
Osimertinib (Tagrisso)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
Cancer Drugs Fund
BlueTeq
 
Link  NICE TA416: Osimertinib for treating locally advanced or metastatic EGFR T790M mutation-positive non-small-cell lung cancer
   
Pemrolizumab (Keytruda®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
Cancer Drugs Fund
BlueTeq

Infusion

 
Link   NICE TA531: Pembrolizumab for untreated PD-L1-positive metastatic non-small-cell lung cancer
Link  MHRA Drug Safety Update: reports of organ transplant rejection - July 2017
Link  NICE TA357: Pembrolizumab for treating advanced melanoma after disease progression with ipilimumab
Link  NICE TA366: Pembrolizumab for advanced melanoma not previously treated with ipilimumab
Link  NICE TA428: Pembrolizumab for treating PD-L1-positive non-small-cell lung cancer after chemotherapy
Link  NICE TA519: Pembrolizumab for treating locally advanced or metastatic urothelial carcinoma after platinum-containing chemotherapy
Link  NICE TA522: Pembrolizumab for untreated locally advanced or metastatic urothelial cancer when cisplatin is unsuitable
Link  NICE TA540: Pembrolizumab for treating relapsed or refractory classical Hodgkin lymphoma
Link  NICE TA553: Pembrolizumab for adjuvant treatment of resected melanoma with high risk of recurrence
Link  NICE TA557: Pembrolizumab with pemetrexed and platinum chemotherapy for untreated, metastatic, non-squamous non-small-cell lung cancer
Link  NICE TA570: Pembrolizumab for treating recurrent or metastatic squamous cell carcinoma of the head and neck after platinum-based chemotherapy (terminated appraisal)
Link  NICE TA600: Pembrolizumab with carboplatin and paclitaxel for untreated metastatic squamous non-small-cell lung cancer
   
Pomalidomide (Imnovid®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
Cancer Drugs Fund
BlueTeq
 
Link  MHRA Safety Update:Pomalidomide (Imnovid): risk of hepatitis B reactivation
Link  MHRA Safety Update:Pomalidomide (Imnovid): risks of cardiac failure, interstitial lung disease and hepatotoxicity
Link  NICE TA388: Pomalidomide for myeloma
Link  NICE TA427: Pomalidomide for multiple myeloma previously treated with lenalidomide and bortezomib
   
Talimogene laherparepvac (Imlygic®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
Cancer Drugs Fund
BlueTeq

injection

 
Link  NICE TA410: Talimogene laherparepvec for treating unresectable metastatic melanoma
   
Teriflunomide (Aubagio®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
Cancer Drugs Fund
NHS England
BlueTeq
 
Link  NICE TA303: Teriflunomide for relapsing remitting MS
Link  NICE TA405:Trifluridine–tipiracil for previously treated metastatic colorectal cancer
   
Thalidomide (Celgene®)
(haematology)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
 
Link  MHRA Alert:Thalidomide: reduced starting dose in patients older than age 75 years
Link  MHRA Safety Alert: Thalidomide: risk of arterial and venous thromboembolism
Link  MHRA Safety Alert:Thalidomide: risk of second primary malignancies
Link  NICE TA228:Bortezomib and thalidomide for the first‑line treatment of multiple myeloma
   
08.02.04  Expand sub section  Interferon Alfa
Interferon Alfa
(IntronA)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
 
Link  NICE TA75: Interferon Alfa - Chronic Hepatitis C
   
Interferon Alfa (Roferon-A®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
 
   
Peginterferon Alfa (Pegasys®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
 
Link  NICE TA106: Hepatitis C - peginterferon alfa & ribavirin
Link  NICE TA200: Hepatitis C - peginterferon alfa & ribavirin
Link  NICE TA300: Hepatitis C - peginterferon alfa
Link  NICE TA75: Hepatitis C - pegylated interferons, ribavirin & alfa interferon
Link  NICE TA96: Hepatitis B - peginterferon alfa
   
Peginterferon Alfa (ViraferonPeg®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
 
   
08.02.04  Expand sub section  Interferon beta
Interferon Beta (Avonex®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
NHS England
BlueTeq

Injection

 
Link  MHRA Drug Safety Alert:Interferon-beta: risk of thrombotic microangiopathy and risk of nephrotic syndrome
Link  NICE TA527: Beta interferons and glatiramer acetate for treating multiple sclerosis
   
Interferon Beta (Betaferon®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
NHS England
BlueTeq

Injection

 
Link  MHRA Drug Safety Alert: Interferon-beta: risk of thrombotic microangiopathy and risk of nephrotic syndrome
Link  NICE TA527:Beta interferons and glatiramer acetate for treating multiple sclerosis
   
Interferon beta (Extavia®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
 
Link  MHRA Drug Safety Alert:Interferon-beta: risk of thrombotic microangiopathy and risk of nephrotic syndrome
Link  NICE TA527:Beta interferons and glatiramer acetate for treating multiple sclerosis
   
Interferon Beta (Rebif®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
NHS England
BlueTeq

injection

 
Link  MHRA Drug Safety Alert: Interferon-beta: risk of thrombotic microangiopathy and risk of nephrotic syndrome
Link  NICE TA32: Interferon Beta for MS
   
Peginterferon Beta-1a (Plegridy®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine

Injection

 
   
08.02.04  Expand sub section  Interferon gamma
08.02.04  Expand sub section  Aldesleukin
08.02.04  Expand sub section  BCG bladder instillation to top
08.02.04  Expand sub section  Canakinumab
08.02.04  Expand sub section  Dimethyl fumarate
08.02.04  Expand sub section  Fingolimod
08.02.04  Expand sub section  Glatiramer acetate
Glatiramer Acetate (Copaxone®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
Cancer Drugs Fund
NHS England
BlueTeq

injection

 
Link  NICE CG32: Glatiramer for the treatment of MS
Link  NICE TA527:Beta interferons and glatiramer acetate for treating multiple sclerosis
   
08.02.04  Expand sub section  Histamine to top
08.02.04  Expand sub section  Lenalidomide, pomalidomide, and thalidomide
08.02.04  Expand sub section  Mifamurtide
Mifamurtide (Mepact®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red

Intravenous Infusion

 
Link  NICE TA235: Osteosarcoma - mifamurtide: guidance
   
08.02.04  Expand sub section  Natalizumab
Natalizumab (Tysabri®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
NHS England
BlueTeq

injection

 
Link  MHRA Drug Safety Alert:Natalizumab (Tysabri¨‹): progressive multifocal leukoencephalopathy¡ªupdated advice to support early detection
Link  NICE TA127: Multiple sclerosis - natalizumab
   
08.02.04  Expand sub section  Teriflunomide
08.03  Expand sub section  Sex hormones and hormone antagonists in malignant disease to top
08.03.01  Expand sub section  Oestrogens
08.03.02  Expand sub section  Progestogens
Medroxyprogesterone Acetate (Provera®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber

Tablet

Red injection

Red for treatment of oncology indications

 
   
08.03.03  Expand sub section  Androgens
08.03.04  Expand sub section  Hormone antagonists
08.03.04.01  Expand sub section  Breast cancer to top
Anastrozole
(Breast cancer)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber

1mg Tablet

 
   
Exemestane
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber

Tablets 25mg

 
   
Fulvestrant (Faslodex®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red

Injection

 
Link  NICE TA239: Fulvestrant for the treatment of locally advanced or metastatic breast cancer
   
Goserelin (Zoladex®)
(Breast cancer)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber

Injection 3.6mg, 10.8mg

 
   
Letrozole
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber

Tablet

 
   
Tamoxifen
(Breast cancer/ mastocytosis)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber

Tablets 10mg, 20mg.

 
   
Toremifene (Fareston®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber

Tablets 60mg

 
   
08.03.04.02  Expand sub section  Prostate cancer and gonadorelin analogues
Radium-223 dichloride
(Xofigo®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
Cancer Drugs Fund
 
Link  NICE TA376: Radium-223 dichloride for treating hormone-relapsed prostate cancer with bone metastases
Link  NICE TA412: Radium-223 dichloride for treating hormone-relapsed prostate cancer with bone metastases
   
08.03.04.02  Expand sub section  Gonadorelin analogues
Degarelix (Firmagon®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red

injection

 
Link  NICE TA404: Degarelix for treating advanced hormone-dependent prostate cancer
   
08.03.04.02  Expand sub section  Anti-androgens
Abiraterone (Zytiga®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
NHS England
BlueTeq

tablet

 
Link  NICE TA259: Abiraterone for castration resistant prostate cancer
Link  NICE TA387:Abiraterone for treating metastatic hormone-relapsed prostate cancer before chemotherapy is indicated
   
Bicalutamide
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber

50mg and 150mg tablets

 
   
Buserelin
(Prostate)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
 
   
Cyproterone
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber

Tablet

 
   
Enzalutamide (Xtandi®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine

capsule

 
Link  NICE TA316: Enzalutamide for prostate cancer
Link  NICE TA377: Enzalutamide for treating metastatic hormone-relapsed prostate cancer before chemotherapy is indicated
   
Flutamide
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red

Tablets

 
   
Goserelin (Zoladex®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber

3.6mg  Injection

 
   
Goserelin (Zoladex® LA)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber

10.8mg Injection

 
   
Leuprorelin Acetate (Prostap® 3)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber

11.25mg Injection

 
   
Leuprorelin Acetate (Prostap® SR)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber

3.75mg Injection

 
   
Triptorelin (Decapeptyl®)
(Malignancy)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber

Injection

 
   
08.03.04.03  Expand sub section  Somatostatin analogues
Lanreotide
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber
High Cost Medicine

Injection - Prefilled syringe

 
   
Octreotide (Sandostatin Lar®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine

50 mcg/ml, 100 mcg/ml injection

 
   
Octreotide (Sandostatin®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine

injection

 
   
 ....
 Non Formulary Items
Vinblastine Sulphate  (Velbe®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
  
Key
note Notes
Section Title Section Title (top level)
Section Title Section Title (sub level)
First Choice Item First Choice item
Non Formulary Item Non Formulary section
Restricted Drug
Restricted Drug
Unlicensed Drug
Unlicensed
Track Changes
Display tracking information
click to search medicines.org.uk
Link to adult BNF
click to search medicines.org.uk
Link to children's BNF
click to search medicines.org.uk
Link to SPCs
SMC
Scottish Medicines Consortium
Cytotoxic Drug
Cytotoxic Drug
CD
Controlled Drug
High Cost Medicine
High Cost Medicine
Cancer Drugs Fund
Cancer Drugs Fund
NHSE
NHS England
Homecare
Homecare
CCG
CCG

Traffic Light Status Information

Status Description

Green

Green -Medicines suitable for routine use within primary care and Secondary care Can be initiated within primary care within their licensed indication, in accordance with nationally recognised formularies  

Amber

Amber- Medicines suitable to be prescribed in primary care after specialist /Consultant recommendation or initiation. A supporting prescribing guideline may be requested which must have been agreed by the relevant secondary care trust Medicines and Therapeutic Committee and approved by the Area Prescribing Committee.   

Red

Red-Hospital initiation and continuation only  

Amber Shared Care Protocol

AMBER SHARE CARE PROTOCOL- Medicines that should be initiated by a specialist and prescribed by primary care prescribers only under a shared care protocol, once the patient has been stabilised  

Blue

To be supplied from the appropriate commissioned provider.   

Green 2

GREEN 2- to be prescribed by primary care only   

Grey

GREY- NON FORMULARY (As agreed by Area Prescribing Committee)  

netFormulary