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 Formulary Chapter 5: Infections - Full Chapter
Notes:

The Antibiotic Formulary and Prescribing Advice for Adult Patients should be read in conjunction with this chapter -  aim is to encourage the appropriate use of this valuable resource.

 

Antibiotic prescribing for primary care can be viewed via this link

Guidance on Antibiotic in Primary care

 Details...
05.01  Antibacterial drugs
05.01  Table 1. Summary of antibacterial therapy
05.01  Table 2. Summary of antibacterial prophylaxis
05.01.01  Penicillins
05.01.01.01  Benzylpenicillin and phenoxymethylpenicillin to top
Benzylpenicillin
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Formulary
Green

Injection

 
 
Phenoxymethylpenicillin
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Formulary
Green

Tablets

Syrup

 
 
Procaine Benzylpenicillin
(Centre for Sexual Health Only)
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Formulary
Red
 
 
Benzathine Penicillin
(Centre for Sexual Health Only)
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Formulary
Red
 
 
05.01.01.02  Penicillinase-resistant penicillins
Flucloxacillin
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Formulary
Green

Capsules

Syrup

 
 
Flucloxacillin
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Formulary
Red

Injection

 
 
Temocillin
(Hospital Only)
View adult BNF View SPC online View childrens BNF  Track Changes
Restricted Drug Restricted
Red

Injection

Restricted use only requiring microbiologist approval in all cases

 
 
05.01.01.03  Broad-spectrum penicillins
Amoxicillin
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Formulary
Green

Capsules

Syrup

Sachets

 

 
 
Amoxicillin
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Formulary
Red

injection

 
 
Co-Amoxiclav
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Formulary
Green

Tablets, Dispersible Tablets, Suspension

 

To be prescribed in accordance with local antimicrobial guidance and guidance from health protection agency

 
 
Co-Amoxiclav
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Formulary
Red

Injection

 
 
05.01.01.04  Antipseudomonal penicillins
Piperacillin and Tazobactam
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Formulary
Red

Injection

 

Restricted Item restricted by indication as per the antibiotic guideline

 
 
Ticarcillin
(Hospital Only)
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Formulary
Red

Injection

 

Restricted Item Group 3 restricted

 
 
05.01.01.05  Mecillinams
Pivmecillinam (® selexid )
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Formulary
Green

Tablets

Restricted Item Group 2 Restricted

For resistant urinary tract infection where no alternative oral agent is suitable. Shown by microbiogical culture and sensitivities

 
 
05.01.02  Cephalosporins, carbapenems and other beta-lactums to top
05.01.02  Cephalosporins
05.01.02  Other beta-lactam antibiotics
05.01.02.01  Cephalosporins
Cefalexin
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Formulary
Green

Capsules, Syrup, Tablets

restricted to indication. To be used in accordance with the local antibitic guidance and guidance from health protection agency

 
 
Cefixime
(Centre for Sexual Health Only)
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Formulary
Red

Tablets

 
 
Cefotaxime
(Hospital Only)
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Formulary
Red

Injection - for Meningitis and Neonatal Use Only

 
 
Ceftazidime
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Formulary

Green For use in meningitis

Red For other indications

 
 
Ceftobiprole
(Hospital Only)
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Formulary
Red

Injection

 
 
Ceftriaxone
(injection)
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Formulary

Green For pelvic inflammatory disease or for emergency treatment of suspected bacterial meningitis

Red For all other indications

 
 
Cefuroxime
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Formulary
Red

Injection

 
 
05.01.02.02  Carbapenems
Ertapenem
(Hospital Only)
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Restricted Drug Restricted
Red

solution for infusion

Microbiologist Approval required in all cases

 
 
Imipenem with Cilastatin
(Hospital Only)
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Restricted Drug Restricted
Red

Injection

Group 3 restricted.

Microbiology approval is required in all cases

 
 
Meropenem
(Hospital Only)
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Restricted Drug Restricted
Red

Injection

Group 2 restricted due to 9 permitted indications.

To be used in accordance with antimicrobial guidance and health protection agency guidance

 
 
05.01.02.03  Other beta-lactums antibiotics to top
Aztreonam
(Hospital Only)
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Formulary
Red

Injection

Group three restricted

Microbiologist authorisation only

 
 
05.01.03  Tetracyclines
Doxycycline
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Formulary
Green

Capsules

Dispersible Tablets

 
 
Lymecycline (Tetralysal® 300)
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Formulary
Green

Capsules

 
 
Oxytetracycline
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Formulary
Green

Tablets

 
 
Demeclocycline
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Restricted Drug Restricted
Red

Capsules

Restricted ItemLimited clinical use in context of antibiotic. Sometimes indicated for endocrine indications such as SIADH. Hence warranting restrited use

 
 
05.01.03  Tigecycline
05.01.04  Aminoglycosides
Amikacin
(Hospital Only)
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Formulary
Red

Injection

 
 
Gentamicin
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Formulary
Red

Injection

 
 
Neomycin
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Formulary
Amber

Tablets, Syrup

 

Specialist initiation only

 
 
Tobramycin
(Nebulised)
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Formulary
Red
High Cost Medicine

nebuliser solution

 
 
Tobramycin
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Formulary
Red

 

Injection

 

 

 
 
Tobramycin inhaler (TOBI Podhaler®)
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Formulary
Red
High Cost Medicine

Inhaler

 
Link  NICE TA276: Cystic fibrosis (pseudomonas lung infection) - colistimethate sodium and tobramycin
 
05.01.05  Macrolides
Azithromycin
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Green

Capsules, Suspension

 
Link  NICE ESUOM37-Cystic fibrosis: long term azithromycin
Link  NICE ESUOM38 - Non-cystic fibrosis bronchiectasis: long-term azithromycin
 
Clarithromycin
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Formulary
Green

Injection, Tablets, Suspension, Sachets

 
 
Erythromycin
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Formulary
Green

Talets

Use in pregnancy or if there is a known intolerance to clarithromycin

 

 

 
 
Erythromycin
(Erythromycin lactobionate)
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Formulary
Red

Lactobionate Injection - Hospital Only - GI motility agent only 

 
 
Erythromycin
(Erythromycin ethyl succinate)
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Restricted Drug Restricted
Green

Erythromycin ethyl succinate mixture

 
 
Clarithromycin  (Klaricid ® )
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Restricted Drug Restricted
Green

for Lower repsirtory tract infections 

 
 
05.01.06  Clindamycin to top
Clindamycin
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Restricted Drug Restricted
Green

Use of Clindamycin is restricted by indication. Consult Antimicrobial Guidance before use

Green   Capsules

 

Red Traffic Light    Injection

Red Traffic Light   Suspension - Hospital Paediatric Use Only unlicensedunlicensed

 
 
05.01.07  Some other antibacterials
Fidaxomicin
(Hospital Only)
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Formulary
Amber

200mg Tablets - Requires Microbiologist authorisation 

Suitable for Primary care to prescribe provided there is authorisation from a microbiologist

 
 
Rifaximin
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Formulary
Red

550mg  tablets

Indicated for the prophylaxis of encephalopathy to be used in accordance with NICE TA337

 
Link  NICE TA337: Rifaximin for preventing episodes of overt hepatic encephalopathy
 
Spectinomycin
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Formulary
Red

Centre for Sexual Health Only

 
 
Tedizolid (Sivextro®)
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Formulary
Red

200mg Tablets, Infusion

 

Microbiology Approval is requires in all cases

 
 
Tigecycline
(Hospital Only )
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Formulary
Red

Injection
Microbiologist approval required in all cases

 
 
05.01.07  Chloramphenicol
Chloramphenicol
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Formulary
Red

Capsule, Injection

 

Microbiology Approval is required

 
 
05.01.07  Fosfomycin
Fosfomycin
(Hospital Only )
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Formulary
Green

Green  3g Oral Sachets

Not be used first line and must be used in accordance with culture and sensitivity results.

For treatment resistant UTI licenced for women, doses change as per gender

 

Red  Injection ( unlicensedUnlicensed )

 
 
05.01.07  Fusidic acid
Sodium fusidate
 Track Changes
Formulary
Red

Tablet, Suspension, Infusion
Microbiologist approval required in all cases

 
 
05.01.07  Vancomycin and teicoplanin to top
Teicoplanin
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red

Injection

 
 
Vancomycin
(IV)
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Formulary
Red

Injection

 
 
Vancomycin
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Formulary
Green

Green Capsules

 

 

 
 
05.01.07  Daptomycin
Daptomycin
(Hospital Only)
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Formulary
Red

Injection

Microbiology approval required

 
 
05.01.07  Linezolid
Linezolid
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Restricted Drug Restricted
Red

Tablet, Injection
Microbiologist approval required in all cases

 
 
05.01.07  Quinupristin and dalfopristin
05.01.07  Polymyxins
Colistimethate (® colomycin)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red

Injection
Microbiologist approval required in all cases

 
Link  NICE [ESUOM25]Non-cystic fibrosis bronchiectasis: colistimethate sodium
 
Colistimethate for nebulisation (Colobreathe®)
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Formulary
Red
High Cost Medicine

Capsule - dry powder for inhalation
For the management of chronic pulmonary infections caused by P.aeruginosa in patients with cystic fibrosis (CF)

 
Link  MHRA Safety update: Colobreathe (colistimethate sodium dry powder for inhalation): risk of capsule breakage - new instructions for use
Link  NICE TA276: Cystic fibrosis (pseudomonas lung infection) - colistimethate sodium and tobramycin
 
Colistimethate for nebulisation (Promixin®)
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Formulary
Red
High Cost Medicine

Nebule
"Restricted by Indication"

 
 
05.01.07  Fidaxomicin to top
Fidaxomicin (Dificlir®)
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Formulary  
 
05.01.08  Sulphonamides and trimethoprim
Co-trimoxazole (Septrin®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Green

Green  Tablet 480mg, Suspension

 

Red  Injection

 
 
Sulfadiazine
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Formulary
Red

Tablets

 
 
Trimethoprim
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Formulary
Green

Green Tablets, Suspension

 

Red Injection

 
 
05.01.09  Antituberculosis drugs
Ethambutol
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Formulary
Red

tablet

unlicensed unlicensed  - Ethambutol Liquid. Consultant Paediatrician Only (unlicenced & specials)

 
 
Isoniazid
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Formulary
Red

Tablet, Injection
Elixir 50mg/5ml - Unlicensed

 
 
Pyrazinamide
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Formulary
Red

tablet

unlicensed unlicenced - Pyrazinamide Liquid. Consultant Paediatrician Only

 
 
Rifampicin
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red

Capsules, Syrup, Injection

 
 
Rifampicin and Isoniazid (Rifinah® 300 Rifinah® 150)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red

tablet

 
 
Rifampicin and Isoniazid (Rimactazid® 300)
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Formulary
Red

tablet

 
 
Rifampicin and Isoniazid and Pyrazinamide (Rifater®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red

tablet

 
 
Rifampicin, isoniazid, pyrazinamide and ethambutol (Voractiv®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red

tablet

 
 
Streptomycin Sulphate
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Formulary
Red

Injection

 
 
05.01.10  Antileprotic drugs
Dapsone
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Formulary
Red

tablet

 
 
05.01.11  Metronidazole and tinidazole
05.01.12  Quinolones to top
Ciprofloxacin
View adult BNF View SPC online View childrens BNF  Track Changes
Restricted Drug Restricted
Green

'Restricted by Indication'

 

Green Tablet, Suspension

 

Red  Injections 'prescribed in hospital only'

 
Ofloxacin
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Second Choice
Green

Tablet
"Restricted by Indication" - see list in Antibiotic guidelines

Second line sometimes used for epididymitis/ orchitis as better tolerated

 
 
Levofloxacin
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red

Tablet

Restricted Item Levofloxacin Infusion 500mg/100ml  restricted use only

 
 
Moxifloxacin
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Formulary
Red

Tablets

Injection

 
 
05.01.13  Urinary-tract infections
Nitrofurantoin
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First Choice
Green

Tablets, Capsules, Modified Release Capsules,  Suspension

1st line for simple cystitis

 
Trimethoprim
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First Choice
Green
 
Methenamine Hippurate (Hiprex®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber

Tablets – Following Urologist recommendation only

Features in Primary care document

 
 
05.02  Antifungal drugs
Amphotericin (Abelcet ® AmBisome ® Fungizone ®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine

Infusion

 
 
Fluconazole
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Formulary
Red

Injection, Infusion

 
 
Itraconazole
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Formulary
Green

Capsules, Liquid

 
 
Ketoconazole (Nizoral®)
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Formulary
Green

Shampoo

 
 
Terbinafine
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Green

Tablet

 
 
Voriconazole (Vfend®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine

Tablets, Injection

 
Link  MHRA Alert: Voriconazole: reminder of risk of liver toxicity, phototoxicity, and squamous cell carcinoma
 
05.02  Treatment of fungal infections
05.02  Drugs used in fungal infections
Fluconazole (Diflucan®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Green

Capsule, Suspension

 
 
Nystatin (Nystan®)
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Formulary
Green

Oral suspension 100 000 units per mL

 
 
Terbinafine (Lamisil®)
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Formulary
Green

Terbinafine hydrochloride 1%

Topical preparation, please consult chapter 13 for further information

 
 
05.02.01  Triazole antifungals to top
05.02.02  Imidazole antifungals
05.02.03  Polyene antifungals
05.02.04  Echinocandin antifungals
Anidulafungin (Ecalta®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine

infusion

 
 
Caspofungin (Cancidas®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
 
 
05.02.05  Other antifungals
05.03  Antiviral drugs to top
05.03.01  HIV infection
 note 

Hull University Teaching Hospitals NHS Trust is commissioned to provide HIV services. Please see the Hull and East Riding Prescribing Committee website for formulary status.

https://www.hey.nhs.uk/wp/wp-content/uploads/2016/03/redList.pdf

Cobicistat (Tybost®)
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Formulary
Red
High Cost Medicine

Tablet

 
 
Tenofovir alafenamide, elvitegravir, cobicistat & emtricitabine (Genvoya®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine

Tablet
Restricted to use in accordance with the NHS England commissioning guidance 

 
Link  MHRA Alert: Cobicistat, ritonavir and coadministration with a steroid: risk of systemic corticosteroid adverse effects
 
05.03.01  Nucleoside reverse transcriptase inhibitors
Abacavir (Ziagen®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine

Tablet, Oral Solution

 
 
Abacavir and Lamivudine (Kivexa®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine

Tablet

 
 
Abacavir and Lamivudine and Zidovudine (Trizivir®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine

Tablet

 
 
Didanosine (Videx®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine

Tablet

Capsule

 
 
Emtricitabine (Emtriva®)
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Formulary
Red
High Cost Medicine

Capsule, Oral Solution

 
 
Emtricitabine 200mg, Rilpivirine 25mg and Tenofovir 245mg (Eviplera®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine

Tablet

 
 
Lamivudine (Epivir®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine

Tablet
Oral Solution

 
Link  NICE CG165 : Hepatitis B (chronic): diagnosis and management
 
Lamivudine (Zeffix®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine

Tablet

 
Link  NICE CG165: Chronic Hepatitis B
 
Rilpivirine hydrochloride (Edurant®)
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Formulary
Red
High Cost Medicine

Tablet

 
 
Stavudine (Zerit®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine

Capsule, Oral Solution 

 
 
Tenofovir 245mg, Efavirenz 600mg and Emtricitabine 200mg (Atripla®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine

Tablet

 
 
Tenofovir and Emtricitabine (Truvada®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine

Tablet

 
 
Tenofovir Disproxil (Viread®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine

Tablet

 
Link  NICE TA173: Hepatitis B (chronic) - tenofovir disoproxil
 
Tenofovir, cobicistat, elvitegravir & emtricitabine (Stribild®)
View adult BNF View SPC online View childrens BNF  Track Changes
Restricted Drug Restricted
Red
High Cost Medicine

Tablet
Restricted to use in accordance with the NHS England commissioning guidance.

 
Link  MHRA Alert: Cobicistat, ritonavir and coadministration with a steroid: risk of systemic corticosteroid adverse effects
 
Zidovudine (Retrovir®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine

Capsule

 
 
Zidovudine and Lamivudine (Combivir®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red

Tablet

 
 
05.03.01  Protease inhibitors
Atazanavir (Reyataz®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine

Capsule

 
 
Fosamprenavir (Telzir®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine

Tablet, Oral Suspension

 
 
Lopinavir and Ritonavir (Kaletra®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine

Tablet
Liquid

 
 
Ritonavir (Norvir®)
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Formulary
Red
High Cost Medicine

Tablet
Note: Doses differ according to formulation used and thus tablets and chewable tablets are not equivalent. When prescribing, the formulation must be specified

 
 
Saquinavir (Invirase®)
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Formulary
Red
High Cost Medicine

Tablet

 
 
05.03.01  Non-nucleoside reverse transcriptase inhibitors
Efavirenz (Sustiva®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine

Capsule, Tablet

 
 
Etravirine (Intelence®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine

Tablet

 
 
Nevirapine (Viramune®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine

Tablet, Suspension, Tablet MR

 
 
05.03.01  Other antiretrovirals to top
Dolutegravir (tivicay ®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine

Tablet

 
 
Dolutegravir, abacavir & lamivudine (Triumeq®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine

Tablet

 
 
Maraviroc (Celsentri®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine

Tablet

Oral Solution

 
 
Raltegravir (Isentress ®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine

Tablet
Note: Doses differ according to formulation used and thus tablets and chewable tablets are not equivalent. When prescribing, the formulation must be specified

 
 
05.03.02  Herpesvirus infections
05.03.02.01  Herpes simplex and varicella-zoster infection
Aciclovir
View adult BNF View SPC online View childrens BNF  Track Changes
First Choice
Green

Green   Tablet, Suspension

 

Red   Injection & Infusion

 
Famciclovir (Famvir®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Green 2

Tablet

 
 
Valaciclovir (Valtrex®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber

Tablets

*Only to be prescribed on advice of microbiologist. Indication for treatment of HSV PCR Positive viral meningitis ( not for encephalitis for which iv aciclovir must be used)*

 
 
05.03.02.02  Cytomegalovirus infection
Ganciclovir (Cymevene®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine

Infusion

 
 
Letermovir
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
 
Link  NICE TA591: Letermovir for preventing cytomegalovirus disease after a stem cell transplant
 
Valganciclovir (Valcyte®)
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Formulary
Red
High Cost Medicine

Tablet, Oral solution

Prevention of cytomegalovirus disease following solid organ transplantion.
Complete course should be provided from transplant centre - not funded for prescribing in primary care 

 
 
05.03.03  Viral hepatitis
05.03.03.01  Chronic hepatitis B to top
Adefovir Dipivoxil (Hepsera®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine

Tablet

 
Link  NICE CG165: Hepatitis B (chronic) - incorporates TA96
Link  NICE TA96: Hep B - adefovir dipivoxil and pegylated interferon alpha-2a
 
Entecavir (Baraclude®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine

Tablet
Use in accordance with NICE guidance  

 
Link  NICE CG165: Hepatitis B (incorporates TA153)
Link  NICE TA153: Hepatitis B (chronic) - etecavir
 
05.03.03.02  Chronic hepatitis C
Boceprevir (Victrelis®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
NHS England

capsule

 
Link  MHRA Alert: Boceprevir (Victrelis) and telaprevir (Incivo): predictive factors for sepsis, worsening liver function, and mortality
Link  NICE TA253: hepatitis
 
Daclatasvir  (Daklinza®)
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Restricted Drug Restricted
Red
High Cost Medicine
NHS England

Tablet

 
Link  NICE TA364: Daclatasvir for treating chronic hepatitis C
Link  MHRA Alert: Sofosbuvir with daclatasvir; sofosbuvir and ledipasvir: risks of severe bradycardia and heart block when taken with amiodarone
 
Dasabuvir (Exviera®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
NHS England

Tablet

 
Link  NICE TA365: Ombitasvir–paritaprevir–ritonavir with or without dasabuvir for treating chronic hepatitis C
 
Elbasvir/Grazoprevir (Zepatier®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
NHS England
 
Link  NICE TA413: Elbasvir–grazoprevir for treating chronic hepatitis C
 
Glecaprevir and Pibrentasvir (Maviret®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
NHS England
BlueTeq

Tablet

 
Link  NICE TA499: Glecaprevir–pibrentasvir for treating chronic hepatitis C
 
Ledipasvir and Sofosbuvir (Harvoni®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
NHS England

Tablet

 
Link  NICE TAG63: Ledipasvir–sofosbuvir for treating chronic hepatitis C
Link  MHRA Alert: Sofosbuvir with daclatasvir; sofosbuvir and ledipasvir: risks of severe bradycardia and heart block when taken with amiodarone
Link  NICE TA430 : Sofosbuvir–velpatasvir for treating chronic hepatitis C
 
Ombitasvir/ paritaprevir/ ritonavir (Viekirax®)
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Formulary
Red
High Cost Medicine
NHS England

tablet

 
Link  NICE TA365: Ombitasvir–paritaprevir–ritonavir with or without dasabuvir for treating chronic hepatitis C
Link  MHRA Alert: Cobicistat, ritonavir and coadministration with a steroid: risk of systemic corticosteroid adverse effects
 
Sofosbuvir (Sovaldi®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
NHS England

Tablet

 
Link  NICE TA330: Sofosbuvir for treating chronic hepatitis C
Link  MHRA Alert: Sofosbuvir with daclatasvir; sofosbuvir and ledipasvir: risks of severe bradycardia and heart block when taken with amiodarone
 
Sofosbuvir, Velpatasvir and Voxilaprevir (Vosevi®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
NHS England
BlueTeq

Tablet

 
Link  NICE TA507: Sofosbuvir–velpatasvir for treating chronic hepatitis C
 
Telaprevir (Incivo®)
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Formulary
Red
High Cost Medicine
NHS England

Tablet

 
Link  MHRA Alert: Boceprevir (Victrelis) and telaprevir (Incivo): predictive factors for sepsis, worsening liver function, and mortality
Link  NICE TA252: Telaprevir in hepatitis C
 
05.03.04  Influenza
Oseltamivir (Tamiflu®)
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Restricted Drug Restricted
Green

Capsule and suspension

To be used with Public health Guidance

 
Link  MHRA Alert : Oseltamivir (Tamiflu): changed concentration and dosing dispenser of oral suspension
Link  PHE guidance on use of antiviral agents for the treatment and prophylaxis of seasonal influenza
 
Zanamivir  (Dectova®)
(solution for infusion )
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Formulary
Red

Consultant microbiologist authorisation only

 
 
Zanamivir inhalation (Relenza®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
 
 
05.03.05  Respiratory syncytial virus
Palivizumab (Synagis®)
View adult BNF View SPC online View childrens BNF  Track Changes
Restricted Drug Restricted
Red
High Cost Medicine
NHS England
BlueTeq

Injection

 
 
Ribavirin
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
NHS England
BlueTeq

Tablet

Capsule

 
Link  NICE TA106: Hepatitis C - peginterferon alfa and ribavirin
Link  NICE TA200: Hepatitis C - peginterferon alfa and ribavirin
Link  NICE TA300:Hepatitis C (children and young people) - peginterferon alfa and ribavirin
Link  NICE TA75: Hepatitis C - pegylated interferons, ribavirin and alfa interferon
 
05.04  Antiprotozoal drugs
05.04.01  Antimalarials to top
05.04.01  Treatment of malaria
05.04.01  Falciparum malaria (treatment)
05.04.01  Benign malarias (treatment)
05.04.01  Prophylaxis against malaria
05.04.01  Specific recommendations to top
05.04.01  Artemether with lumefabtrine
Artemether with lumefantrine (Riamet®)
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Formulary
Amber

tablets (treatment of uncomplicated Falciparum)

 
 
05.04.01  Chloroquine
Chloroquine
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Formulary
Green

   GreenTablet, Syrup
     

  Red Injection             

 

 

For the treatment of malaria. Should not be prescribed for malaria    prophylaxis on the NHS. Patients should obtain a supply on private prescription or purchase a supply "over the counter" as appropriate

 
 
05.04.01  Mefloquine
Mefloquine (Lariam®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Green
 
 
05.04.01  Primaquine
05.04.01  Proguanil to top
Proguanil Hydrochloride (Paludrine®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Green

Tablet
For the treatment of malaria
Should not be prescribed for malaria prophylaxis on the NHS. Patients should obtain a supply on private prescription or purchase a supply "over the counter" as appropriate  

 
 
05.04.01  Pyrimethamine
Pyrimethamine with Sulfadoxine (Fansidar®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Green

Tablets

 
 
05.04.01  Quinine
Quinine dihydrochloride
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red

Injection

 
 
Quinine Sulfate
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Green

Tablets

 
 
05.04.01  Tetracyclines
05.04.02  Amoebicides
Diloxanide
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber
 
 
Metronidazole
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Green

Green Tablet, Suspension, Suppository

 

Red Infusion

 
 
05.04.03  Trichomonacides to top
05.04.04  Antigiardial drugs
Mepacrine Hydrochloride
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Green
 
 
05.04.05  Leishmaniacides
05.04.06  Trypanocides
05.04.07  Drugs for toxoplasmosis
05.04.08  Drugs for pneumocystis pneumonia to top
Pentamidine Isetionate (Pantacarinat®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red

Injection

 
 
05.04.08  Treatment
05.04.08  Prophylaxis
05.05  Anthelmintics
05.05.01  Drugs for threadworms
Albendazole
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red

unlicensed unlicensed

Tablet 400mg (unlicensed import, some products are chewable)

Specialist recommendation (discuss specific therapies and investigations with a Microbiologist or an Infectious Disease specialist)

 
 
Mebendazole
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Green

Tablets
Suspension

 
 
05.05.02  Ascaricides to top
Levamisole
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red

unlicensed unlicensed

 

Unlicenced Tablet

 
 
05.05.03  Drugs for tapeworm infections
05.05.03  Taenicides
05.05.03  Hydatid disease
05.05.04  Drugs for hookworms
05.05.05  Schistosomicides to top
PRAZIQUANTEL
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red

unlicensed unlicensed

 

Tablet

Unlicensed medicine - named patient use only

 
 
05.05.06  Filaricides
Diethylcarbamazine
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red

unlicensed unlicensed

 

Tablets

 
 
Ivermectin
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red

unlicensed unlicensed

Tablets

 
Link  NICE ESUOM29: Difficult-to-treat scabies: oral ivermectin. March 2014
 
05.05.07  Drugs for cutaneous larva migrans
TIABENDAZOLE
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red

Tablets

 
 
05.05.08  Drugs for strongyloidiasis
 ....
 Non Formulary Items
Amprenavir  (Agenerase®)

View adult BNF View SPC online View childrens BNF
Non Formulary
Cefadroxil

View adult BNF View SPC online View childrens BNF
Non Formulary
Cefpodoxime

View adult BNF View SPC online View childrens BNF
Non Formulary
Cefradine

View adult BNF View SPC online View childrens BNF
Non Formulary
Ceftaroline  (Zinforo®)

View adult BNF View SPC online View childrens BNF
Non Formulary
Ceftolozane & tazobactam  (Zerbaxa®)

View adult BNF View SPC online View childrens BNF
Non Formulary
Co-Fluampicil

View adult BNF View SPC online View childrens BNF
Non Formulary
Delamanid  (Deltyba®)

View adult BNF View SPC online View childrens BNF
Non Formulary
High Cost Medicine
Piperazine

View adult BNF View SPC online View childrens BNF
Non Formulary
Piperazine
(With sennosides)

View adult BNF View SPC online View childrens BNF
Non Formulary
Proguanil Hydrochloride
(With chloroquine)

View adult BNF View SPC online View childrens BNF
Non Formulary
  
Key
note Notes
Section Title Section Title (top level)
Section Title Section Title (sub level)
First Choice Item First Choice item
Non Formulary Item Non Formulary section
Restricted Drug
Restricted Drug
Unlicensed Drug
Unlicensed
Track Changes
Display tracking information
click to search medicines.org.uk
Link to adult BNF
click to search medicines.org.uk
Link to children's BNF
click to search medicines.org.uk
Link to SPCs
SMC
Scottish Medicines Consortium
Cytotoxic Drug
Cytotoxic Drug
CD
Controlled Drug
High Cost Medicine
High Cost Medicine
Cancer Drugs Fund
Cancer Drugs Fund
NHSE
NHS England
Homecare
Homecare
CCG
CCG

Traffic Light Status Information

Status Description

Green

Green -Medicines suitable for routine use within primary care and Secondary care Can be initiated within primary care within their licensed indication, in accordance with nationally recognised formularies  

Amber

Amber- Medicines suitable to be prescribed in primary care after specialist /Consultant recommendation or initiation. A supporting prescribing guideline may be requested which must have been agreed by the relevant secondary care trust Medicines and Therapeutic Committee and approved by the Area Prescribing Committee.   

Red

Red-Hospital initiation and continuation only  

Amber Shared Care Protocol

AMBER SHARE CARE PROTOCOL- Medicines that should be initiated by a specialist and prescribed by primary care prescribers only under a shared care protocol, once the patient has been stabilised  

Blue

To be supplied from the appropriate commissioned provider.   

Green 2

GREEN 2- to be prescribed by primary care only   

Grey

GREY- NON FORMULARY (As agreed by Area Prescribing Committee)  

netFormulary